报告人：姚成贵
报告题目：Theoretical Modeling of Dynamic Transitions Among Wakefulness, NREM, and REM Sleep in Healthy Sleep Cycles
报告时间：2025年9月20日（周六）下午5：00
报告地点：物理与电子工程学院428会议室
主办单位：物理与电子工程学院、科学技术研究院
报告人简介：
姚成贵博士，嘉兴大学教授。入选浙江省高校领军人才培养计划高层次拔尖人才，浙江省高校中青年学科带头人。2011年于中科院武汉物理与数学研究所获得理学博士学位。主要研究方向：睡眠动力学，非线性动力学，神经动力学及其数学建模。目前发表SCI论文50余篇，主持完成国家自然科学基金面上项目，主持完成国家自然科学基金青年基金项目，浙江省自然科学基金面上项目，中国博士后基金。
报告摘要：
We present a physiologically grounded mean-field model of sleep-wake regulation that unifies wakefulness, NREM ,and REM sleep within a single dynamical framework.Extending the Action-Arousal architecture, we explicitly incorporate wakefulness-specific populations (Action and Arousal) alongside NREM and REM populations, and we embed circadian, ultradian, homeostatic, and REM-pressure drives into the model.Dynamical analysis using a potential-landscape theory and linear stability analysis reveals multiple stable attractors corresponding to wake, NREM, and REM states.
This framework clarifies how parameter variations reshape transition thresholds. Notably, wake maintenance is enhanced by reciprocal arousal-action excitation, which also constrains direct Wake to REM transitions. In contrast, the NREM-REM cycle appears largely insensitive to reciprocal arousal-action excitation, indicating a modular separation between wake stability and the core NREM-REM oscillator. Our formulation reproduces key features of human sleep architecture, including robust NREM-REM ultradian cycling (~90 minutes) embedded within a broader ~24-hour sleep–wake rhythm, with realistic transition sequences and hysteresis between states.The framework offers a versatile, testable platform for exploring sleep regulation, with potential translational relevance to insomnia, hypersomnia, REM sleep disorders, and chronotherapy.